Comprehensive Psychiatry
Volume 53, Issue 2 , Pages 130-139, February 2012

Placing symptoms in context: the role of contextual criteria in reducing false positives in Diagnostic and Statistical Manual of Mental Disorders diagnoses

  • Jerome C. Wakefield

      Affiliations

    • Silver School of Social Work, New York, NY 10003, USA
    • Department of Psychiatry, School of Medicine, New York University, New York, NY 10016, USA
    • InSPIRES (Institute for Social and Psychiatric Initiatives–Research, Education and Services), Bellevue Hospital/New York University, New York, NY 10016, USA
    • Division of Clinical Phenomenology, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 212 932 9705.
  • ,
  • Michael B. First

      Affiliations

    • Division of Clinical Phenomenology, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    • New York State Psychiatric Institute, New York, NY 10032, USA

published online 12 May 2011.

Abstract 

Purpose

The Diagnostic and Statistical Manual of Mental Disorders (DSM) definition of mental disorder requires that symptoms be caused by a dysfunction in the individual; when dysfunction is absent, symptoms represent normal-range distress or eccentricity and, if diagnosed as a mental disorder, are false positives. We hypothesized that because of psychiatry's lack of direct laboratory tests to distinguish dysfunction from normal-range distress, the context in which symptoms occur (eg, lack of imminent danger in a panic attack) is often essential to determining whether symptoms are caused by a dysfunction. If this is right, then the DSM diagnostic criteria should include many contextual criteria added to symptom syndromes to prevent dysfunction false positives. Despite their potential importance, such contextual criteria have not been previously reviewed. We, thus, systematically reviewed DSM categories to establish the extent of such uses of contextual criteria and created a typology of such uses.

Results

Of 111 sampled categories, 68 (61%) used context to prevent dysfunction false positives. Contextual criteria fell into 7 types: (1) exclusion of specific false-positive scenarios; (2) requiring that patients experience preconditions for normal responses (eg, requiring that individuals experience adequate sexual stimulation before being diagnosed with sexual dysfunctions); (3) requiring that symptoms be disproportionate relative to circumstances; (4) for childhood disorders, requiring that symptoms be developmentally inappropriate; (5) requiring that symptoms occur in multiple contexts; (6) requiring a substantial discrepancy between beliefs and reality; and (7) a residual category.

Conclusions

Most DSM categories include contextual criteria to eliminate false-positive diagnoses and increase validity of descriptive criteria. Future revisions should systematically evaluate each category's need for contextual criteria.

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 Dr. Wakefield has no financial relationship with commercial interests or other conflicts of interest to report. Dr. First receives royalties from books related to DSM-IV (eg, DSM-IV Guidebook) and consults to pharmaceutical companies to provide diagnostic training for clinical trials. In the past 12 months, he has consulted with Cephalon, GlaxoSmithKline, Memory Pharmaceuticals, WorldwideClinical Trials, and i3 research.

PII: S0010-440X(11)00029-0

doi:10.1016/j.comppsych.2011.03.001

Comprehensive Psychiatry
Volume 53, Issue 2 , Pages 130-139, February 2012