Comprehensive Psychiatry
Volume 51, Issue 3 , Pages 243-249 , May 2010

Moderators and mediators among panic, agoraphobia symptoms, and suicidal ideation in patients with panic disorder

  • Mei-Feng Huang

      Affiliations

    • Department of Psychiatry, Kai-Suan Psychiatric Hospital, Kaohsiung, 802 Taiwan
  • ,
  • Cheng-Fang Yen

      Affiliations

    • Department of Psychiatry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807 Taiwan
    • Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, 809 Taiwan
  • ,
  • For-Wey Lung

      Affiliations

    • Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, 802 Taiwan
    • Graduate Institute of Behavioral Sciences, Kaohsiung Medical University, Kaohsiung, 807 Taiwan
    • Department of Psychiatry, National Defense Medical Center, Taipei, 114 Taiwan
    • Calo Psychiatric Center, Pingtung County, 925 Taiwan
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung city 802, Taiwan. Tel.: +886 7 749 0056; fax: +886 7 749 3767.

References 

  1. Widiger TA, Samuel DB. Diagnostic categories or dimensions? A question for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. J Abnorm Psychol. 2005;114(4):494–504
  2. Frank E, Cassano GB, Shear MK, Rotondo A, Dell-Osso L, Mauri M, et al. The spectrum model: a more coherent approach to the complexity of psychiatric symptomatology. CNS Spectr. 1998;3:23–34
  3. Carpiniello B, Baita A, Carta MG, Sitzia R, Macciardi AM, Murgia S. Clinical and psychosocial outcome of patients affected by panic disorder with or without agoraphobia: results from a naturalistic follow-up study. Eur Psychiatry. 2002;17(7):394–398
  4. Noyes R, Clancy J, Woodman C, Holt CS, Suelzer M, Christiansen J. Environmental factors related to the outcome of panic disorder. A seven-year follow-up study. J Nerv Ment Dis. 1993;181(9):529–538
  5. Biederman J, Petty CR, Hirshfeld-Becker DR, Henin A, Faraone SV, Fraire M, et al. Developmental trajectories of anxiety disorders in offspring at high risk for panic disorder and major depression. Psychiatry Res. 2007;153(3):245
  6. Fyer AJ, Mannuzza S, Chapman TF, Martin LY, Klein DF. Specificity in familial aggregation of phobic disorders. Arch Gen Psychiatry. 1995;52(7):564–573
  7. Johnson J, Weissman MM, Klerman GL. Panic disorder, comorbidity, and suicide attempts. Arch Gen Psychiatry. 1990;47(9):805–808
  8. Weissman MM, Klerman GL, Markowitz JS, Ouellette R. Suicidal ideation and suicide attempts in panic disorder and attacks. N Engl J Med. 1989;321(18):1209–1214
  9. Sareen J, Cox BJ, Afifi TO, de Graaf R, Asmundson GJ, ten Have M, et al. Anxiety disorders and risk for suicidal ideation and suicide attempts: a population-based longitudinal study of adults. Arch Gen Psychiatry. 2005;62(11):1249–1257
  10. Bolton JM, Cox BJ, Afifi TO, Enns MW, Bienvenu OF, Sareen J. Anxiety disorders and risk for suicide attempts: findings from the Baltimore Epidemiologic Catchment Area Follow-up Study. Depress Anxiety. 2008;25(6):477–481
  11. Hawgood J, De Leo D. Anxiety disorders and suicidal behaviour: an update. Curr Opin Psychiatry. 2008;21(1):51–64
  12. Hornig CD, McNally RJ. Panic disorder and suicide attempt. A reanalysis of data from the Epidemiologic Catchment Area Study. Br J Psychiatry. 1995;167(1):76–79
  13. Warshaw MG, Dolan RT, Keller MB. Suicidal behavior in patients with current or past panic disorder: five years of prospective data from the Harvard/Brown Anxiety Research Program. Am J Psychiatry. 2000;157(11):1876–1878
  14. Sareen J, Houlahan T, Cox BJ, Asmundson GJ. Anxiety disorders associated with suicidal ideation and suicide attempts in the National Comorbidity Survey. J Nerv Ment Dis. 2005;193(7):450–454
  15. Schmidt NB, Woolaway-Bickel K, Bates M. Evaluating panic-specific factors in the relationship between suicide and panic disorder. Behav Res Ther. 2001;39(6):635–649
  16. Noyes R, DuPont RL, Pecknold JC, Rifkin A, Rubin RT, Swinson RP, et al. Alprazolam in panic disorder and agoraphobia: results from a multicenter trial. II. Patient acceptance, side effects, and safety. Arch Gen Psychiatry. 1988;45(5):423–428
  17. Ballenger JC, Burrows GD, DuPont RL, Lesser IM, Noyes R, Pecknold JC, et al. Alprazolam in panic disorder and agoraphobia: results from a multicenter trial. I. Efficacy in short-term treatment. Arch Gen Psychiatry. 1988;45(5):413–422
  18. Jacobs RJ, Davidson JR, Gupta S, Meyerhoff AS. The effects of clonazepam on quality of life and work productivity in panic disorder. Am J Manag Care. 1997;3(8):1187–1196
  19. Rapaport MH, Pollack M, Wolkow R, Mardekian J, Clary C. Is placebo response the same as drug response in panic disorder?. Am J Psychiatry. 2000;157(6):1014–1016
  20. Stahl SM. Independent actions on fear circuits may lead to therapeutic synergy for anxiety when combining serotonergic and GABAergic agents. J Clin Psychiatry. 2002;63(10):854–855
  21. Stahl SM, Gergel I, Li D. Escitalopram in the treatment of panic disorder: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2003;64(11):1322–1327
  22. Nesse RM, Zamorski MA. Anxiety disorders in primary care. In:  Knespar DJ,  Riba MB,  Schwenk TL editor. Primary care psychiatry. Philadelphia: Saunders; 1997;p. 132–162
  23. Hansson L, Middelboe T, Merinder L, Bjarnason O, Bengtsson-Tops A, Nilsson L, et al. Predictors of subjective quality of life in schizophrenic patients living in the community. A Nordic multicentre study. Int J Soc Psychiatry. 1999;45(4):247–258
  24. Koivumaa-Honkanen HT, Viinamaki H, Honkanen R, Tanskanen A, Antikainen R, Niskanen L, et al. Correlates of life satisfaction among psychiatric patients. Acta Psychiatr Scand. 1996;94(5):372–378
  25. Yanos PT, Rosenfield S, Horwitz AV. Negative and supportive social interactions and quality of life among persons diagnosed with severe mental illness. Community Ment Health J. 2001;37(5):405–419
  26. Jaracz K, Kozubski W. Quality of life in stroke patients. Acta Neurol Scand. 2003;107(5):324–329
  27. Yen CF, Tsai JJ, Lu PL, Chen YH, Chen TC, Chen PP, et al. Quality of life and its correlates in HIV/AIDS male outpatients receiving highly active antiretroviral therapy in Taiwan. Psychiatry Clin Neurosci. 2004;58(5):501–506
  28. Boulenger JP, Uhde TW. Acute anxiety attacks and phobia. Historical aspects and clinical manifestations of the agoraphobia syndrome. Ann Med Psychol. 1987;145(2):113–131
  29. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 3rd ed. Washington, DC: American Psychiatric Association; 1980;
  30. Klein DF. Anxiety reconceptualized. In:  Klein DF,  Rabkin J editor. Anxiety: new research and changing concepts. New York: Raven Press; 1981;
  31. American Psychiatric Association . Diagnostic and statistical manual of mental disorders: DSM-III-R. Washington, DC: American Psychiatric Association; 1987;
  32. Nocon A, Wittchen HU, Beesdo K, Bruckl T, Hofler M, Pfister H, et al. Differential familial liability of panic disorder and agoraphobia. Depress Anxiety. 2008;25(5):422–434
  33. Bienvenu OJ, Onyike CU, Stein MB, Chen LS, Samuels J, Nestadt G, et al. Agoraphobia in adults: incidence and longitudinal relationship with panic. Br J Psychiatry. 2006;188:432–438
  34. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59(Suppl 20):22–33[quiz 34-57]
  35. American Psychiatric Association . Diagnostic and Statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994;
  36. Wang YH. Study on life quality and its associated factors of rheumatoid arthritis patients. J Chang Gung Inst Technol. 1999;2:108–120
  37. Barrera M, Sandler IN, Ramsay TB. Preliminary development of a scale of social support: studies on college students. Am J Community Psychol. 1981;9(4):435
  38. Rin H, Schooler C, Caudill WA. Symptomatology and hospitalization. Culture, social structure and psychopathology in Taiwan and Japan. J Nerv Ment Dis. 1973;157(4):296–312
  39. Cox BJ, Direnfeld DM, Swinson RP, Norton GR. Suicidal ideation and suicide attempts in panic disorder and social phobia. Am J Psychiatry. 1994;151(6):882–887
  40. Pollack MH, Allgulander C, Bandelow B, Cassano GB, Greist JH, Hollander E, et al. WCA recommendations for the long-term treatment of panic disorder. CNS Spectr. 2003;8(8 Suppl 1):17–30
  41. Frank E, Cyranowski JM, Rucci P, Shear MK, Fagiolini A, Thase ME, et al. Clinical significance of lifetime panic spectrum symptoms in the treatment of patients with bipolar I disorder. Arch Gen Psychiatry. 2002;59(10):905–911
  42. Frank E, Shear MK, Rucci P, Cyranowski JM, Endicott J, Fagiolini A, et al. Influence of panic-agoraphobic spectrum symptoms on treatment response in patients with recurrent major depression. Am J Psychiatry. 2000;157(7):1101–1107
  43. Hasin D, Grant B, Endicott J. Treated and untreated suicide attempts in substance abuse patients. J Nerv Ment Dis. 1988;176(5):289–294
  44. Noyes R, Christiansen J, Clancy J, Garvey MJ, Suelzer M, Anderson DJ. Predictors of serious suicide attempts among patients with panic disorder. Compr Psychiatry. 1991;32(3):261–267
  45. Hirschfeld RM. Panic disorder: diagnosis, epidemiology, and clinical course. J Clin Psychiatry. 1996;57(Suppl 10):3–8[discussion 9-10]
  46. Lepola U, Koponen H, Leinonen E. A naturalistic 6-year follow-up study of patients with panic disorder. Acta Psychiatr Scand. 1996;93(3):181–183
  47. Warshaw MG, Massion AO, Peterson LG, Pratt LA, Keller MB. Suicidal behavior in patients with panic disorder: retrospective and prospective data. J Affect Disord. 1995;34(3):235–247
  48. Henriksson MM, Isometsa ET, Kuoppasalmi KI, Heikkinen ME, Marttunen MJ, Lonnqvist JK. Panic disorder in completed suicide. J Clin Psychiatry. 1996;57(7):275–281
  49. Lepine JP, Chignon JM, Teherani M. Suicide attempts in patients with panic disorder. Arch Gen Psychiatry. 1993;50(2):144–149
  50. Noyes R. Suicide and panic disorder: a review. J Affect Disord. 1991;22(1-2):1–11
  51. Coryell W, Noyes R, Clancy J. Excess mortality in panic disorder. A comparison with primary unipolar depression. Arch Gen Psychiatry. 1982;39(6):701–703
  52. Seemuller F, Riedel M, Obermeier M, Bauer M, Adli M, Mundt C, et al. The controversial link between antidepressants and suicidality risks in adults: data from a naturalistic study on a large sample of in-patients with a major depressive episode. Int J Neuropsychopharmacol. 2008;1–9
  53. Todder D, Baune BT. Recurrence of suicidal ideation due to treatment with antidepressants in anxiety disorder: a case report. J Med Case Rep. 2007;1:166
  54. Lung FW, Lee MB. The five-item Brief-Symptom Rating Scale as a suicide ideation screening instrument for psychiatric inpatients and community residents. BMC Psychiatry. 2008;8:53–60

PII: S0010-440X(09)00084-4

doi: 10.1016/j.comppsych.2009.07.005

Comprehensive Psychiatry
Volume 51, Issue 3 , Pages 243-249 , May 2010