Comprehensive Psychiatry
Volume 48, Issue 5 , Pages 436-440, September 2007

Worsening of psychosis in schizophrenia is longitudinally associated with tardive dyskinesia in the European Schizophrenia Outpatient Health Outcomes study

  • Diederik E. Tenback

      Affiliations

    • Psychiatric Center Altrecht, P.O. Box 18, 3734 ZG Den Dolder, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 348 427111; fax: +31 348 427160.
    • ,
  • Peter N. van Harten

      Affiliations

    • Psychiatric Center Symfora Group, P.O. Box 3051, 3800 DB Amersfoort, The Netherlands
    • University Medical Center Groningen, Groningen, The Netherlands
    • ,
  • Cees J. Slooff

      Affiliations

    • Department of Psychotic Disorders, Mental Health Centre Drenthe, Assen, The Netherlands
    • ,
  • Jim van Os

      Affiliations

    • Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    • Division of Psychological Medicine, Institute of Psychiatry, London, UK
    • ,
  • SOHO Study Group

published online 05 July 2007.

Abstract 

Objective

The objective of the study was to examine if worsening of psychosis predicts the emergence of tardive dyskinesia (TD).

Method

Global measures of TD and Clinical Global Impression (CGI) overall symptom severity score were rated in 4 assessments in 12 months. In a risk set free of TD at baseline, associations between TD onset and change in CGI scores were assessed using Cox proportional hazard regression.

Results

A total of 8620 patients yielded 23565 follow-up observations, 8.8% of which represented a worsening in CGI overall symptom severity relative to the previous observation, yielding an incidence of TD of 5.2%, compared with 2.7% in observations without worsening of psychopathology (rate ratio, 1.9; 95% confidence interval, 1.3-2.7). Incidence of TD was longitudinally associated with a worsening of the CGI overall symptom severity in the months preceding TD onset (adjusted hazard ratio over 6 levels of CGI score, 1.3; 95% confidence interval, 1.1-1.4).

Conclusion

Worsening in overall psychopathology in schizophrenia is longitudinally associated with the emergence of TD as measured by CGI overall symptom severity.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0010-440X(07)00059-4

doi:10.1016/j.comppsych.2007.05.003

Comprehensive Psychiatry
Volume 48, Issue 5 , Pages 436-440, September 2007

Article Tools