Is major depressive episode related to anxiety disorders in anorexics and bulimics?

Godart, Nathalie T.; Perdereau, Fabienne; Curt, Florence; Rein, Zoé; Lang, François; Venisse, Jean Luc; Halfon, Olivier; Bizouard, Paul; Loas, Gwenole; Corcos, Maurice; Jeammet, Philippe; Flament, Martine F.

doi:10.1016/j.comppsych.2005.07.001

« Previous Next »Comprehensive Psychiatry
Volume 47, Issue 2 , Pages 91-98, March 2006

Is major depressive episode related to anxiety disorders in anorexics and bulimics?☆

Nathalie T. Godart
- Department of Psychiatry, Institut Mutualiste Montsouris (IMM), Université Paris V Paris, Unité INSERM U 669 PSIGIAM, France
- Corresponding author. Department of Psychiatry, Institut Mutualiste Montsouris, 75014 Paris, France. Tel.: +33 1 56 61 69 35; fax: +33 1 56 61 69 34.
Fabienne Perdereau
- Department of Psychiatry, Institut Mutualiste Montsouris (IMM), Université Paris V Paris, Unité INSERM U 669 PSIGIAM, France
Florence Curt
- Department of Psychiatry, Institut Mutualiste Montsouris (IMM), Université Paris V Paris, Unité INSERM U 669 PSIGIAM, France
Zoé Rein
- Department of Psychiatry, Institut Mutualiste Montsouris (IMM), Université Paris V Paris, Unité INSERM U 669 PSIGIAM, France
François Lang
- Department of Psychiatry, Centre Hospitalier Universitaire de Saint Etienne, France
Jean Luc Venisse
- Department of Psychiatry, Hôpital Saint Jacques–Unité des addictionsNantes
Olivier Halfon
- Service universitaire de Psychiatrie de l'enfant et de l'adolescent Lausanne–Suisse
Paul Bizouard
- Department of Psychiatry, Centre Hospitalier Universitaire de Besançon, France
Gwenole Loas
- Department of Psychiatry, Secteur Hospitalo–Universitaire P. Pinel Amiens, France
Maurice Corcos
- Department of Psychiatry, Institut Mutualiste Montsouris (IMM), Université Paris V Paris, Unité INSERM U 669 PSIGIAM, France
Philippe Jeammet
- Department of Psychiatry, Institut Mutualiste Montsouris (IMM), Université Paris V Paris, Unité INSERM U 669 PSIGIAM, France
Martine F. Flament
- Department of Psychiatry, University of Ottawa, Royal Ottawa Hospital, Ontario, Canada

Abstract

Objective

To determine whether the presence of anxiety disorders is related to depressive comorbidity in subjects with eating disorders (ED), while taking into account certain variables that may be related to depression (subjects' age, ED duration, prior incidents of anorexia nervosa in bulimic subjects, inpatient or outpatient status, nutritional state [as measured by body mass index]).

Method

We evaluated the frequency of depressive disorders in 271 subjects presenting with a diagnosis of either anorexia nervosa or bulimia, using the Mini International Neuropsychiatric Interview, DSM-IV version.

Results

A multivariate analysis reveals that anxiety disorders do not all have the same influence in terms of risk of onset of major depressive episode in anorexics and bulimics when adjusted on variables related to depression.

Conclusion

Depression in subjects with ED can be explained in part by comorbidity with obsessive-compulsive disorder, generalized anxiety, social phobia, and panic disorder.