Comprehensive Psychiatry
Volume 47, Issue 2 , Pages 136-143 , March 2006

Neuropsychological profile of cognitively impaired patients with schizophrenia

  • Vasilis P. Bozikas

      Affiliations

    • 2nd Department of Psychiatry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
    • Corresponding Author InformationCorresponding author. 58100 Giannitsa, Greece. Tel.: +30 2310647224; fax +30 2310991577.
    • ,
  • Mary H. Kosmidis

      Affiliations

    • Department of Psychology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
    • ,
  • Grigoris Kiosseoglou

      Affiliations

    • Department of Psychology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
    • ,
  • Athanasios Karavatos

      Affiliations

    • 1st Department of Psychiatry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece

References 

  1. Green MF. Schizophrenia revealed: from neurons to social interactions. Norton: New York; 2001;
  2. Harvey PD, Sharma T. Understanding and treating cognition in schizophrenia: a clinician's handbook. London: Martin Dunitz; 2002;
  3. Hoff AL, Riordan H, O'Donnel DW, Morris L, DeLisi LE. Neuropsychological functioning of first-episode schizophreniform patients. Am J Psychiatry. 1992;149:898–903
  4. Mohamed S, Paulsen JS, O'Leary D, Arndt S, Andreasen N. Generalized cognitive deficits in schizophrenia. Arch Gen Psychiatry. 1999;56:749–754
  5. Cannon TD, Bearden CE, Hollister JM, Rosso IM, Sanchez LE, Hadley T. Childhood cognitive functioning in schizophrenia patients and their unaffected siblings: a prospective cohort study. Schizophr Bull. 2000;26:379–393
  6. David AS, Malmberg A, Brandt L, Allebeck P, Lewis G. IQ and risk for schizophrenia: a population-based cohort study. Psychol Med. 1997;27:1311–1323
  7. Jones P, Rodgers B, Murray R, Marmot M. Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet. 1994;344:1398–1402
  8. Allen DN, Goldstein G, Warnick E. A consideration of neuropsychologically normal schizophrenia. J Int Neuropsychol Soc. 2003;9:56–63
  9. Heinrichs RW, Awad AG. Neurocognitive subtypes of chronic schizophrenia. Schizophr Res. 1993;9:49–58
  10. Holthausen EAE, Wiersma D, Sitskoorn MM, Hijman R, Dingemans PM, Schene AH, et al. Schizophrenic patients without neuropsychological deficits: subgroup, disease severity or cognitive compensation?. Psychiatry Res. 2002;112:1–11
  11. Kremen WS, Seidman LJ, Faraone SV, Toomey R, Tsuang MT. The paradox of normal neuropsychological function in schizophrenia. J Abnorm Psychol. 2000;109:743–752
  12. Palmer BW, Heaton RK, Paulsen JS, Kuck J, Braff D, Harris MJ, et al. Is it possible to be schizophrenic yet neuropsychologically normal?. Neuropsychology. 1997;11:437–446
  13. Vinogradov S, Adcock RA, Fischer A, Poole JH. Neurocognitive findings in schizophrenic subjects with above average IQ. Biol Psychiatry. 2000;47:23S
  14. Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology. 1998;12:426–445
  15. Kremen WS, Seidman LJ, Faraone SV, Tsuang MT. Intelligence quotient and neuropsychological profiles in patients with schizophrenia and in normal volunteers. Biol Psychiatry. 2001;50:453–462
  16. Seaton BE, Goldstein G, Allen DN. Sources of heterogeneity in schizophrenia: the role of neuropsychological functioning. Neuropsychol Rev. 2001;11:45–67
  17. Weickert TW, Goldberg TE, Gold JM, Bigelow LB, Egan MF, Weinberger DR. Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect. Arch Gen Psychiatry. 2000;57:907–913
  18. Goldman RS, Bates J, Bilder RM, Conley J, Reiter G, Papadopoulos E, et al. Reverse cohort analysis of preserved neurocognitive function in first-episode schizophrenia. Schizophr Res. 1999;36:131
  19. Chapman LJ, Chapman JM. Disordered thought in schizophrenia. New York: Appleton, Century, Crofts; 1973;
  20. Blanchard JJ, Neale JM. The neuropsychological signature of schizophrenia: generalized or differential deficit?. Am J Psychiatry. 1994;151:40–46
  21. Braff DL, Heaton R, Kuck J, Cullum M, Moranville J, Grant I, et al. The generalized pattern of neuropsychological deficits in outpatients with chronic schizophrenia with heterogeneous Wisconsin Card Sorting Test results. Arch Gen Psychiatry. 1991;48:891–898
  22. Sullivan EV, Shear PK, Zipursky RB, Sagar HJ, Pfefferbaum A. A deficit profile of executive, memory, and motor functions in schizophrenia. Biol Psychiatry. 1994;36:641–653
  23. Hoff AL, Sakuma M, Wieneke M, Horon R, Kushner M, DeLisi LE. Longitudinal neuropsychological follow-up study of patients with first-episode schizophrenia. Am J Psychiatry. 1999;156:1336–1341
  24. Albus M, Hubmann W, Ehrenberg C, Forcht U, Mohr F, Sobizack N, et al. Neuropsychological impairment in first-episode and chronic schizophrenic patients. Eur Arch Psychiatry Clin Neurosci. 1996;246:249–255
  25. Albus M, Hubmann W, Mohr F, Scherer J, Sobizack N, Franz U, et al. Are gender differences in neuropsychological performance in patients with first-episode schizophrenia?. Schizophr Res. 1997;28:39–50
  26. Censits DM, Ragland JD, Gur RC, Gur RE. Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: a longitudinal study. Schizophr Res. 1997;24:289–298
  27. Hutton SB, Puri BK, Duncan L-J, Robbins TW, Barnes TRE, Joyce EM. Executive function in first-episode schizophrenia. Psychol Med. 1998;28:463–473
  28. Saykin AJ, Shtasel DL, Gur RE, Kester DB, Mozley LH, Stafiniak P, et al. Neuropsychological deficits in neuroleptic naïve patients with first-episode schizophrenia. Arch Gen Psychiatry. 1994;51:124–131
  29. Elliot R, McKenna PJ, Robbins TW, Sahakian BJ. Neuropsychological evidence for frontostriatal dysfunction in schizophrenia. Psychol Med. 1995;25:619–630
  30. Heaton R, Paulsen JS, McAdams LA, Kuck J, Zisook S, Braff D, et al. Neuropsychological deficits in schizophrenics: relationship to age, chronicity, and dementia. Arch Gen Psychiatry. 1994;51:469–476
  31. Saykin AJ, Gur RC, Gur RE, Mozley PD, Mozley LH, Resnick SM, et al. Neuropsychological function in schizophrenia: selective impairment in memory and learning. Arch Gen Psychiatry. 1991;48:618–624
  32. Seidman LJ, Kremen WS, Koren D, Faraone SV, Goldsteinm JM, Tsuang MT. A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses. Schizophr Res. 2002;53:31–44
  33. Cannon TD, Zorrilla LE, Shtasel D, Gur RE, Gur RC, Marco EJ, et al. Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Arch Gen Psychiatry. 1994;51:651–661
  34. Allen DN, Goldstein G, Weiner C. Differential neuropsychological patterns of frontal- and temporal-lobe dysfunction in patients with schizophrenia. Schizophr Res. 2001;48:7–15
  35. Riley EM, McGovern D, Mockler D, Doku VCK, ÓCeallaigh S, Fannon DG, et al. Neuropsychological functioning in first-episode psychosis—evidence of specific deficits. Schizophr Res. 2000;43:47–55
  36. American Psychiatric Association . DSM-IV: diagnostic and statistical manual of mental disorders. 4th ed.. Washington (DC): American Psychiatric Press; 1994;
  37. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59(Suppl 20):22–33
  38. Lykouras E, Botsis A, Oulis P. The Positive and Negative Syndrome Scale (PANSS) (in Greek). Athens: Tsiveriotis Ed; 1994;
  39. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13:261–276
  40. Opler LA, Kay SR, Lindenmayer J, Fiszbein A. SCI-PANSS. Toronto: Multi-Health Systems Inc; 1992;
  41. Chouinard G, Ross-Chouinard A, Annable L, Jones BD. Extrapyramidal rating scale. Can J Neurol Sci. 1980;7:233
  42. Owens DGC. A guide to the extrapyramidal side-effects of antipsychotic drugs. Cambridge: Cambridge University Press; 1999;
  43. Heaton RK, Chelune GJ, Talley JL, Kay GG, Curtiss G. Wisconsin Card Sorting Test. Odessa (Fla): Psychological Assessment Resources; 1993;
  44. Stroop JR. Studies of interference in series verbal reactions. J Exp Psychol. 1935;18:643–662
  45. Reitan RM. Validity of the Trail Making Test as an indicator of organic brain damage. Percept Mot Skills. 1958;8:271–276
  46. Vlahou CH, Kosmidis MH. The Greek Trail Making Test: preliminary normative data for clinical and research use. Psychology (in Greek). 2002;9:336–352
  47. Palmer BW, Heaton RK. Executive dysfunction in schizophrenia. In:  Sharma T,  Harvey P editor. Cognition in schizophrenia: impairments, importance and treatment strategies. New York: Oxford University Press; 2000;p. 51–72
  48. Wechsler D. Manual for the Wechsler Adult Intelligence Scale. 3rd ed.. San Antonio (Tex): Psychological Corporation; 1997;
  49. Wechsler D. Wechsler Memory Scale–third edition: administration and scoring manual. San Antonio (Tex): Psychological Corporation; 1997;
  50. Folia V, Kosmidis MH. Assessment of memory skills in illiterates: strategy differences or test artefacts?. Clin Neuropsychol. 2003;17:143–152
  51. Delis DC, Kramer JH, Kaplan E, Ober BA. California Verbal Learning Test (CVLT): research edition. New York: Psychological Corporation; 1987;
  52. Taylor EM. Psychological appraisal of children with cerebellar deficits. Cambridge: Harvard University Press; 1959;
  53. Jones-Gotman M, Milner B. Design Fluency: the invention of nonsense drawings after focal cortical lesions. Neuropsychologia. 1977;15:653–674
  54. Kosmidis MH, Vlahou CH, Panagiotaki P, Kiosseoglou G. The verbal fluency task in the Greek population: normative data and clustering and switching strategies. Int J Neuropsychol Soc. 2004;10:164–172
  55. Hooper HE. The Hooper Visual Organization Test. Los Angeles (Calif): Western Psychological Services; 1957;
  56. Pantelis C, Maruff P. The cognitive neuropsychiatric approach to investigating the neurobiology of schizophrenia and other disorders. J Psychosom Res. 2002;53:655–664
  57. Pantelis C, Wood SJ, Maruff P. Schizophrenia. In:  Harrison JE,  Owen AM editor. Cognitive deficits in brain disorders. London: Martin Dunitz; 2002;p. 217–248
  58. Owen AM. The neuropsychological sequelae of frontal lobe damage. In:  Harrison JE,  Owen AM editor. Cognitive deficits in brain disorders. London: Martin Dunitz; 2002;p. 79–97
  59. Pearlson GD, Marsh L. Structural brain imaging in schizophrenia: a selective review. Biol Psychiatry. 1999;46:627–649
  60. Andreasen NC, O'Leary DS, Flaum M, Nopoulos P, Watkins GL, Boles Ponto LL, et al. “Hypofrontality” in schizophrenia: disturbed dysfunctional circuits in neuroleptic naïve patients. Lancet. 1997;349:1730–1734
  61. Carter CS, Perlstein W, Ganguli R, Brar J, Mintun M, Cohen JD. Functional hypofrontality and working memory dysfunction in schizophrenia. Am J Psychiatry. 1998;155:1285–1287
  62. Walter H, Wunderlich AP, Blankenhorn M, Schäfer S, Tomczak R, Spitzer M, et al. No hypofrontality, but absence of prefrontal lateralization comparing verbal and spatial memory in schizophrenia. Schizophr Res. 2003;61:175–184
  63. Green MF, Kern RS, Braff DL, Mintz J. Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”?. Schizophr Bull. 2000;26:119–136
  64. Fucetola R, Seidman LJ, Kremen WS, Faraone SV, Goldstein JM, Tsuang MT. Age and neuropsychologic function in schizophrenia: a decline in executive abilities beyond that observed in healthy volunteers. Biol Psychiatry. 2000;48:137–146
  65. Rushe TM, Woodruff PWR, Murray RM, Morris RG. Episodic memory and learning in patients with chronic schizophrenia. Schizophr Res. 1999;35:85–96
  66. Venneri A, Bartolo A, McCrimmon S, Clair DS. Memory and dating of past events in schizophrenia. J Int Neuropsychol Soc. 2002;8:861–866
  67. Aleman A, Hijman R, de Haan EHF, Kahn RS. Memory impairment in schizophrenia: a meta-analysis. Am J Psychiatry. 1999;156:1358–1366
  68. Johnsrude IS. The neuropsychological consequences of temporal lobe lesions. In:  Harrison JE,  Owen AM editor. Cognitive deficits in brain disorders. London: Martin Dunitz; 2002;p. 37–57
  69. Nelson MD, Saykin AJ, Flashman LA, Riordan HJ. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study. Arch Gen Psychiatry. 1998;55:433–440
  70. Van Erp TGM, Saleh PA, Rosso IM, Huttunen M, Lönnqvist J, Pirkola T, et al. Contributions of genetic risk and fatal hypoxia to hippocampal volume in patients with schizophrenia or schizoaffective disorder, their unaffected siblings, and healthy volunteers. Am J Psychiatry. 2002;159:1514–1520
  71. Joyal CC, Laasko MP, Tiihonen J, Syvälahti E, Vilkman H, Laasko A, et al. A volumetric MRI study of the entorhinal cortex in first episode neuroleptic-naïve schizophrenia. Biol Psychiatry. 2002;51:1005–1007
  72. Heckers S, Rauch SL, Goff D, Savage CR, Schacter DL, Fischman AJ, et al. Impaired recruitment of the hippocampus during conscious recollection in schizophrenia. Nat Neurosci. 1998;1:318–323
  73. Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia?. Am J Psychiatry. 1996;153:321–330
  74. Schuepbach D, Keshavan MS, Kmiec JA, Sweeney JA. Negative symptom resolution and improvements in specific cognitive deficits after acute treatment in first-episode schizophrenia. Schizophr Res. 2002;53:249–261
  75. Manning L. Assessment and treatment of disorders of visuospatial, imaginal, and constructional processes. In:  Halligan PW,  Kischka U,  Marshall JC editor. Handbook of clinical neuropsychology. New York: Oxford University Press; 2003;p. 181–194
  76. Harvey PD, Keefe RSE. Cognitive impairment in schizophrenia and the implications of atypical neuroleptic treatment. CNS Spectr. 1997;2:1080–1086

PII: S0010-440X(05)00061-1

doi: 10.1016/j.comppsych.2005.05.002

Comprehensive Psychiatry
Volume 47, Issue 2 , Pages 136-143 , March 2006

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