Comprehensive Psychiatry
Volume 45, Issue 4 , Pages 304-310 , July 2004

Does comorbid anxiety or depression affect clinical outcomes in patients with post-traumatic stress disorder and alcohol use disorders?

  • Lawrence A. Labbate

      Affiliations

    • Mental Health Service, VA Medical Center, Charleston, SC, USA
    • Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    • Corresponding Author InformationAddress reprint requests to Lawrence A. Labbate, M.D., 109 Bee St, #116, Charleston, SC 29401 USA
    • ,
  • Susan C. Sonne

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    • ,
  • Carrie L. Randal

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    • ,
  • Raymond F. Anton

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA
    • ,
  • Kathleen T. Brady

      Affiliations

    • Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA

References 

  1. Brown C, Schulberg HC, Madonia MJ, Shear MK, Houck PR. Treatment outcomes for primary care patients with major depression and lifetime anxiety disorders. Am J Psychiatry. 1996;153:1293–1300
  2. Pollack MH, Otto MW, Sachs GS, Leon A, Shear MK, Deltito JA, et al.  Anxiety psychopathology predictive of outcome in patients with panic disorder and depression treated with imipramine, alprazolam and placebo. J Affect Disord. 1994;30:273–281
  3. Feske U, Frank E, Mallinger AG, Houck PR, Fagiolini A, Shear MK, et al.  Anxiety as a correlate of response to the acute treatment of bipolar I disorder. Am J Psychiatry. 2000;157:956–962
  4. Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB. Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry. 1995;52:1048–1060
  5. Keane TM, Kaloupek DG. Comorbid psychiatric disorders in PTSD. Implications for research. Ann NY Acad Sci. 1997;821:24–34
  6. Breslau N, Davis GC, Andreski P, Peterson E. Traumatic events and posttraumatic stress disorder in an urban population of young adults. Arch Gen Psychiatry. 1991;48:216–222
  7. Kaufman J, Charney D. Comorbidity of mood and anxiety disorders. Depress Anxiety. 2000;12(Suppl 1):69–76
  8. Brady KT, Killeen TK, Brewerton T, Lucerini S. Comorbidity of psychiatric disorders and posttraumatic stress disorder. J Clin Psychiatry. 2000;61(Suppl 7):22–32
  9. Brady KT. Posttraumatic stress disorder and comorbidity (recognizing the many faces of PTSD). J Clin Psychiatry. 1997;58(Suppl 9):12–15
  10. Marshall EJ, Alam F. Psychiatric problems associated with alcohol misuse and dependence. Br J Hosp Med. 1997;8:44–46
  11. Connor KM, Hidalgo RB, Crockett B, Malik M, Katz RJ, Davidson JR. Predictors of treatment response in patients with posttraumatic stress disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2001;25:337–345
  12. Davidson J, Kudler H, Smith R, Mahorney SL, Lipper S, Hammett E, et al.  Treatment of posttraumatic stress disorder with amitriptyline and placebo. Arch Gen Psychiatry. 1990;47:259–266
  13. Brady K, Sonne S, Killeen TK, Randall K, Anton R. Sertraline in Comorbid PTSD/Alcohol Dependence. 2003; Poster Presentation at the College on Problems of Drug Dependence, Bal Harbour, FL, June 15–19
  14. American Psychiatric Association . Diagnostic and Statistical Manual IV. Washington, DC: APA Press; 1994;
  15. Kadden RM. Project MATCH (treatment main effects and matching results). Alcohol Clin Exp Res. 1996;20:196A–197A
  16. Blake DD, Weathers FW, Nagy LM, Kaloupek DG, Gusman FD, Charney DS, et al.  The development of a Clinician-Administered PTSD Scale. J Trauma Stress. 1995;8:75–90
  17. First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for DMS-IV Axis I Disorders, Patient Edition, version 2. New York, NY: New York State Psychiatric Institute, Biometrics Research; 1995;
  18. Miller WR. Manual for Form 90 (A Structured Assessment Interview for Drinking and Related Behaviors). Rockville, MD: National Institute on Alcohol Abuse and Alcoholism; 1996;
  19. Hamilton M. A Rating Scale for Depression. J Neurol Neurosurg Psychiatry. 1960;23:56–62
  20. Keane TM, Kaloupek DG. Comorbid psychiatric disorders in PTSD. Implications for research. Ann NY Acad Sci. 1997;821:24–34
  21. Brady KT, Clary CM. Affective and anxiety comorbidity in PTSD treatment trials of sertraline. Comp Psychiatry. In Press
  22. Johnson BA, Roache JD, Javors MA, DiClemente CC, Cloninger CR, Prihoda TJ, et al.  Ondansetron for reduction of drinking among biologically predisposed alcoholic patients (A randomized controlled trial). JAMA. 2000;284:963–971

PII: S0010-440X(04)00051-3

doi: 10.1016/j.comppsych.2004.03.015

Comprehensive Psychiatry
Volume 45, Issue 4 , Pages 304-310 , July 2004

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