Twenty-year behavioral follow-up of a 1;13 chromosomal translocation and mobius syndrome presenting with poor impulse control, exhibitionism, and aggression

Abstract 

Mobius syndrome is a rare disorder characterized by agenesis or aplasia of the facial or abducens nerve motor nuclei and other features including central nervous system and behavioral abnormalities. We report an adult case of Mobius syndrome variant presenting with poor impulse control, aggression, and exhibitionism. Karyotyping revealed a 46 XY, t(1;13)(p34.3;q12.3) translocation. The subject had been presented 20 years previously as the index case of a three-generation pedigree.