| | The structure of affective symptoms in a sample of young adults☆☆☆★Abstract Symptoms of bipolar disorders include depression and mania. The term “bipolar” implies states that are opposite to each other. Construing scales that define mania and depression as opposite ends of one dimension cannot account for the existence of mixed symptoms. One self-report instrument, the Internal State Scale (ISS), combines both dimensions in one measure. However, the ISS only assesses internal subjective states and does not tap other typical and more objective symptoms of (hypo-) mania. To explore the factorial structure of affective symptoms in a general population sample, we extended the Center for Epidemiologic Studies-Depression Scale (CES-D), adding items to assess manic symptoms as described in DSM-IV. The scale was completed by 2,059 young adults. The results for the original CES-D are comparable to prior studies. Factor-analysis for the extended CES-D revealed two factors in women and men: most manic symptoms loaded high on a factor “euphoria-activation,” whereas the other factor included all typical dysphoric-depressive symptoms, but also included the “manic symptoms” of distractibility and irritability. Our results support a two-factor model of bipolar symptoms in the general population with irritability being more closely associated with dysphoria than euphoria. The implications and limitations of the present results are discussed. Copyright 2003, Elsevier Science (USA). All rights reserved.
About 50 years ago Kleist and his student Leonard introduced the distinction between unipolar affective and bipolar affective disorders.1, 2 Originally unipolar affective disorders included patients who only showed depressive episodes or who only showed manic episodes. Today, unipolar affective disorders has almost become a synonym for unipolar depression. Discussion about the prevalence of unipolar mania is, however, still controversial.3, 4, 5, 6, 7, 8
Typically, the course of bipolar disorder is described as switches between manic or hypomanic episodes and depressive episodes with intermittent or without euthymic phases. The term “bipolar” implies that this disorder involves states that are opposite to each other, and some of the symptoms appear as true opposites, e.g., depression versus euthymia, loss of energy versus feeling energetic, increased need for sleep or sleeping disorders versus decreased need for sleep.8, 9 However, construing and using scales for assessing manic and depressive symptoms that conceptualize the symptoms of bipolar disorder as the poles of single dimensions does not adequately take into account the existence of so-called mixed episodes in which manic and depressive symptoms co-occur or rapidly alternate.8, 9, 10, 11 Such mixes states are much more frequent, if one not only considers the restrict criteria of the Diagnostic and Statistical Manual for Mental Disorders8 requiring to fulfill a manic and a major depression episode except for duration, but rather asks for depressed mood only.10, 12
The consequence of the existence of such mixed states or episodes is that both clusters of symptoms always have to be assessed simultaneously when dealing with bipolar disorders. If one searches for appropriate self-rating instruments to assess manic and depressive symptoms, one is faced with the problem that almost all scales only cover one of the two symptom poles, e.g., the Beck Depression Inventory (BDI)13 or the Inventory for Depressive Symptomatology14 versus the Self-Rating Manic Inventory (SRMI)15 or Altman Self-Rating Mania Scale.16 Only one scale has included items to assess both depression and mania with the same response categories and with the same time frame: the Internal State Scale (ISS).17 In the ISS, patients are asked to rate their emotional state for the last 24 hours using 17 items rated on visual analogous scales. There is some evidence that the ISS is a reliable and valid tool for daily protocols in clinical therapy trials.17, 18, 19, 20 Scoring the ISS, however, does not result in a depression and a mania score, because original factor analysis suggested not two but four factors labeled as “activation,” “well-being,” “perceived critics,” and “depression.” Cutoff scores for these four dimensions are proposed to characterize euthymia, mania, depression, or mixed episodes.21 Although this is a promising approach, the ISS items only cover subjective and internal emotional states, not other symptoms of mania and depression, such as changes in sleep or speech rate.
We wanted to investigate the structure of affective symptoms in a general population sample using a self-report instrument that assesses more typical symptoms of hypomania and depressive episodes. Of interest is whether such an instrument would demonstrate a factor structure underlying bipolar symptomatology similar to the results provided by Bauer et al.,17 or if a factor-analysis supports a more “classical” view of two factors, i.e., (hypo-) mania and depression.
Searching for an appropriate instrument to address this question, the General Behavior Inventory22, 23 could have been considered an excellent measure because it is often used to assess both poles, depression and mania, in the general population.22, 23, 24, 25 However, it assesses the symptoms in a more trait-like manner, preferentially identifying cyclothymia and not current affective symptoms. Therefore, we looked for an alternative. For depression, the Center for Epidemiological Studies-Depression Scale (CES-D)26 has been successfully used in numerous studies and in different populations to screen for depression.27, 28, 29, 30 Focusing on a sample from the general population, we therefore decided to use the CES-D and add items that also assess the typical hypomanic symptoms as described in DSM-IV.8
Method  Participants Between fall 1998 and spring 1999, schools in the metropolitan area of Stuttgart to Tuebingen were asked to participate in a research project with the official permission of the Department of Education and Culture of the Baden-Wuerttemberg state. The participants were attending high school or college, or vocational schools providing job training (e.g., mail services, hair cutting, banking). The questionnaire consisted of an extended version of the CES-D (see below) as well as other questions about sociodemographic variables, grades, number of friends, and so on. We received a total of 2,059 questionnaires from young adults. There was a predominance of female subjects in the total sample (61.2 %) The age range was from 18 to 40 years. However, looking at the distribution of age in our sample, we excluded all respondents age 26 or older (n = 42) in order to have a more homogeneous group. The majority of the sample described their nationality as German (n = 1,740, 84.5 %). We found a significant effect of nationality on the CES-D (F [5, 1,843] = 6.07, P < .001). Post-hoc Scheffé test revealed only one significant difference, with Italian individuals scoring higher on the CES-D than Germans. However, we decided to restrict our sample to subjects whose nationality was German. The mean age of the final sample was 19.10 years (SD = 1.49). Sample characteristics are listed in Table 1.
All subjects were given written information approved by the ethical committee of the German Psychological Association (Deutsche Gesellschaft für Psychologie, DGPs), but only those who wished to continue with the study completed a written informed consent paper to ensure anonymity for all others. | | |  | | | | “Depressive” | “Manic” |  |
|---|
 | | % | n | Mean (SD) | Mean (SD) |  |
 | Age group (yr) | | | | |  |
 | 18 | 48.4 | 793 | 15.66 (9.07) | 7.07 (4.22) |  |
 | 19 | 24.6 | 403 | 16.52 (9.87) | 6.88 (4.15) |  |
 | 20 | 12.0 | 196 | 15.28 (8.73) | 6.64 (4.32) |  |
 | 21 | 6.0 | 99 | 16.44 (10.24) | 6.16 (3.41) |  |
 | 22 | 4.3 | 71 | 15.34 (9.32) | 6.27 (4.11) |  |
 | 23-25 | 4.7 | 77 | 13.76 (8.15) | 6.93 (4.28) |  |
 | Sex | | | | |  |
 | Male | 38.6 | 633 | 14.10 (8.55) | 7.15 (4.46) |  |
 | Female | 61.3 | 1003 | 16.84 (9.58) | 6.69 (3.97) |  |
 | Missing | 0.2 | 3 | - | - |  |
 | Education* | | | | |  |
 | No high school diploma | 0.6 | 10 | 14.63 (8.60) | 10.71 (2.43) |  |
 | Low level | 7.3 | 119 | 19.65 (9.04) | 8.48 (4.59) |  |
 | Intermediate level | 32.9 | 539 | 16.14 (9.78) | 7.16 (4.37) |  |
 | High level | 53.8 | 882 | 15.03 (8.84) | 6.43 (3.94) |  |
 | Other or unspecified | 5.4 | 89 | - | - |  |
 | Socioeconomic level† | | | | |  |
 | High | 0.4 | 7 | 12.14 (5.76) | 5.57 (4.50) |  |
 | Medium | 73.0 | 1197 | 15.48 (9.17) | 6.78 (4.08) |  |
 | Low | 22.9 | 375 | 16.70 (9.63) | 7.37 (4.48) |  |
 | Missing information | 3.7 | 60 | - | - |  |
 | Nationality‡ | | | | |  |
 | German | 84.5 | 1740 | 15.80 (9.29) | 6.86 (4.17) |  |
 | Italian | 1.7 | 34 | 22.19 (12.70) | 8.43 (4.22) |  |
 | Turkish | 3.2 | 66 | 19.63 (9.60) | 7.97 (5.32) |  |
 | Yugoslavian | 2.7 | 56 | 18.71 (11.03) | 8.06 (6.05) |  |
 | Greek | 0.8 | 17 | 19.33 (9.82) | 7.45 (4.43) |  |
 | Other (eg, USA) | 3.2 | 66 | - | - |  |
 | Missing information | 3.9 | 80 | - | - |  |
 | *High level of education = 13 years of secondary education (“Abitur”); intermediate level = attending school for 10 years (“Mittlere Reife”); low level = 9 years of education (“Hauptschule”). †The socioeconomic level was determined for this German sample using Kraemer's (1983) financial economic index based on the job of the father and/or mother. ‡The nationality was determined by subjects self-classification. The category “Yugoslavian” is a post-hoc data reduction of all persons coming from former Yugoslavia. |  | | | |
The CES-D and its extension The CES-D originally consists of 20 items assessing depressive symptoms.26, 31 Responses to the items are rated using a four-point scale: 0 (rarely or none of the time), 1 (some or a little of the time), 2 (occasionally or a moderate amount of the time), and 3 (most of the time). For these four points, anchors are described specifying what it means to say “some or a little of the time.” Participants are asked how often they have experienced each of the symptoms during the previous week. The psychometric properties of the German and American CES-D are comparable.32, 33 In the present sample the mean score of the CES-D was 15.75 (SD = 9.28). The mean item difficulty was .78 with a range from .30 to 1.65, and the reliability was Cronbach's α = .87. Table 1 displays the means and standard deviations depending on several sociodemographic variables. For the assessment of hypomanic or manic symptoms the criteria of the DSM-IV8 were used and transformed into questions. The format of the question was the same as the one generally used in the CES-D. Two additional principles were important to us for item development: (1) each DSM-IV criteria had to be covered by at least one question; (2) the instrument should stay as short as possible. The questions were presented in the same response format as the original items of the CES-D. The items were worded as follows: (a) “I was unusually happy, excited or elated”; (b) “My thoughts raced through my mind”; (c) “I was very irritable”; (d) “I was extremely active and occupied myself with several things”; (e) “I was easily distracted and constantly lost my flow of thoughts”; (f) “I hardly needed any sleep nor did I have the desire to sleep”; (g) “I spoke a lot more or faster”; (h) “I thought I possessed special abilities or powers”; and (i) “I couldn't sit still and felt compelled to do something.” The possible range of scores is 0 to 27. In a sample of adolescents the reliability of these nine items proved to be sufficient with α = .65 with a mean score of 7.0. There were some significant associations to sociodemographic variables like sex or age, but they proved to be practically irrelevant according to effect size measures. Depressive and (hypo-) manic symptoms correlated with each other (r = .17; P < .001, n = 3,157).33 In the present sample of young adults the scale mean was 6.88 (SD = 4.17). The item difficulty was .76 with a range from .45 (for item 7) to 1.26 (for item 4), and reliability was Cronbach's α = .68.
Results  CES-D For comparison with other studies using the original CES-D, we first present results for the depression scale only. As expected women had higher CES-D scores than men (t = 5.67, df = 1,406.9, P < .001; d = .29) (see Table 1), while age was not significantly related to depressive symptoms in this sample (F [5, 1,595] = 1.30, difference not significant). High, medium, or low education levels were significantly associated with depression (F [2, 1,461] = 12.66, P < .001). Although the effect size was small (f = 0.13), people having a lower education reported more depressive symptoms for the previous week than the other two groups, which did not differ from each other. Using the recommended clinical cutoff for German samples of 23, about 23.4 % (n = 384) of our sample would be considered as “possibly depressed.” In general, these results resemble the ones obtained in other studies.29, 30, 32, 33 Manic/hypomanic symptoms As stated, we extended the CES-D and also included items for hypomanic and manic episodes. Although our primary goal was to investigate the factorial structure of the affective symptoms all together, we also wanted information about the nine “manic items.” As with depression, we did not find any age effect for the manic symptoms (F [5, 1,595] = 1.30). However, there was an effect of the education level (F [2, 1,503] = 14.74, P < .001) with people having a high education reporting the least (hypo-) manic symptoms, and those with a low education reporting most (hypo-) manic symptoms. However, the effect size was negligible with f = 0.02. Men reported significantly higher scores than women (t = 2.09, df = 1,196.9, P < .05), but the effect size also was negligible (d = 0.07). The sum score of the manic items correlated significantly with the depression score (r = .17, P < .001), which is in accordance with other data and studies.24, 33, 34, 35 Factorial structure of the affective symptoms The difference in rates of depression and depression scores is well documented36, 37, 38; therefore we decided to run the principal component factor analysis separately by gender. To determine the number of factors we used the scree test. The factor analyses for men and for women both resulted in six factors with an eigenvalue greater than 1.00. The variance explained by these factors was 51.1% in the male sample and 53.0% in the female sample. The eigenvalues and variance explained were in the male sample 6.60 (22.8%), 3.32 (11.5%), 1.49 (5.1%), 1.23 (4.2%), 1.12 (3.8%), and 1.07 (3.7%). The equivalent values in the female sample were 7.58 (26.2%), 2.90 (10.0%), 1.41 (4.9%), 1.32 (4.5%), 1.13 (3.9%), and 1.0 (3.5%). In both cases, however, the scree test suggested a two-factor solution. Table 2 lists the factor loadings.
A varimax-rotation led for men and women to a similar factor solution as the unrotated ones. The amount of variance explained by the first two rotated factors was, however, smaller at 24% for men and 29.2% for women. Additionally, the unrotated factor solutions made more sense pertaining to interpretation of the factors. | | |  | | Males | Females |  |
|---|
 | Item | h2 | I | II | h2 | I | II |  |
 | 1. I was bothered by things | .23 | .48 | .01 | .25 | .48 | .14 |  |
 | 2. I did not feel like eating | .10 | .31 | .00 | .09 | .23 | .19 |  |
 | 3. I felt that I could not shake off the blues | .44 | .66 | −.01 | .50 | .69 | −.15 |  |
 | 4. I felt that I was just as good as other people (−)* | .24 | .45 | −.18 | .27 | .48 | −.19 |  |
 | 5. I had trouble keeping my mind on what I was doing | .25 | .48 | .13 | .27 | .46 | .25 |  |
 | 6. I felt depressed | .61 | .76 | −.17 | .67 | .82 | −.01 |  |
 | 7. I felt everything I did was an effort | .29 | .54 | −.00 | .34 | .58 | .00 |  |
 | 8. I felt hopeful about the future (−)† | .14 | −.00 | −.38 | .10 | −.01 | −.31 |  |
 | 9. I though my life had been a failure | .44 | .66 | −.01 | .45 | .67 | .00 |  |
 | 10. I felt fearful | .34 | .58 | .00 | .44 | .66 | .00 |  |
 | 11. My sleep was restless | .19 | .43 | .00 | .21 | .44 | .11 |  |
 | 12. I was happy (−)† | .63 | .60 | −.52 | .61 | .70 | −.35 |  |
 | 13. I talked less than usual | .36 | .60 | −.00 | .33 | .57 | −.00 |  |
 | 14. I felt lonely | .40 | .63 | −.01 | .45 | .67 | −.00 |  |
 | 15. People were unfriendly | .18 | .38 | .19 | .13 | .33 | .13 |  |
 | 16. I enjoyed life (−)† | .52 | .53 | −.49 | .62 | .69 | −.38 |  |
 | 17. I had crying spells | .19 | .44 | .00 | .40 | .62 | .11 |  |
 | 18. I felt sad | .58 | .76 | −.00 | .62 | .79 | .00 |  |
 | 19. I felt that people disliked me | .30 | .55 | .00 | .25 | .47 | .17 |  |
 | 20. I could not get “going” | .22 | .47 | .00 | .23 | .48 | .00 |  |
 | 21. *I was unusually happy, excited or elated | .49 | −.00 | .70 | .54 | −.32 | .66 |  |
 | 22. *My thoughts raced through my mind | .44 | .35 | .56 | .40 | .39 | .50 |  |
 | 23. *I was very irritable | .35 | .56 | .20 | .41 | .64 | .01 |  |
 | 24. *I was extremely active and occupied myself with several things | .27 | −.01 | .52 | .31 | −.26 | .49 |  |
 | 25. *I was easily distracted and constantly lost my flow of thoughts | .31 | .46 | .22 | .35 | .46 | .37 |  |
 | 26. *I hardly needed any sleep nor did I have the desire to sleep | .23 | .11 | .47 | .20 | −.00 | .45 |  |
 | 27. *I spoke a lot more or faster | .39 | .12 | .61 | .34 | −.00 | .58 |  |
 | 28. *I thought I possessed special abilities or powers | .35 | .00 | .59 | .28 | −.01 | .53 |  |
 | 29. *I couldn't sit still and felt compelled to do something | .48 | .27 | .64 | .40 | .14 | .62 |  |
 | Eigenwert | | 6.60 | 3.32 | | 7.58 | 2.90 |  |
 | Explained variance | | 22.8 % | 11.5 % | | 26.2 % | 10.0 % |  |
 | *Items to assess hypomanic or manic symptoms; †(−) These items are inversely scored for the original CES-D, and this is the reason why the factor loadings with the factor I “dysphoria” are positive, while the factor loadings with factor II have negative signs. |  | | | |
The factor loadings in Table 2 show a pattern that suggests that factor I taps “dysphoria/depression” while factor II assesses typical “(hypo-) mania.” The pattern of factor loadings was essentially the same for both sex. We defined a factor loading of at least .40 on one factor as sufficiently high to contribute meaningfully to that factor. Some items, however, did not fulfill this criterion. These were “loss of appetite” (item 2) and “unfriendliness of others” (item 15). The item 8 (“hopefulness about the future”) almost met our criteria to be indicative of mania or hypomania. Interestingly, two of the self-rated DSM symptoms that would be considered indicative of a hypomanic or manic episode loaded higher on the depression factor than on the mania factor: for both men and women, these were “irritability” (item 23) and “distractibility” (item 25).
Discussion  The goal of the present study was to investigate the factorial structure of self-rated affective symptoms. We used an extended version of the CES-D26 that included items to assess (hypo-) manic symptoms as described in the DSM-IV. In this nonclinical sample of young adults, we found for both men and women that affective symptoms can be described with a two-factor model: one dimension covering dysphoric-depressive symptoms, and one covering mania. However, two of the DSM-IV (hypo-) manic symptoms were more closely associated with the depression symptoms than the mania factor in this sample: irritability and distractibility. Examining each factor in more detail, the first factor “depression ” covers all but three of the original CES-D items. However, the items tapping loss of appetite (item 2) and unfriendliness of other people (item 15) still show higher loadings on the depression than the mania factor but did not reach our criteria of a factor loading of at least .40. The item asking for hopelessness about the future (item 8, reversed), however, loaded higher on mania than on depression. This is not surprising as the two other inversely coded depression items of the original CES-D, happiness and enjoying life, also load on the factor “mania.” Other studies often find a four-factor solution for the CES-D items differentiating depressed affect, (lack of) well-being, somatic symptoms, and interpersonal difficulties.30, 39, 40 The items representing the (lack of) well-being factor are the before mentioned inversely coded depression items of the original CES-D, which would be more closely related to euphoria and mania in our analysis. Although scales only aimed at measuring depression may have their own structures with more than one dimensions,30, 39 within the frame of bipolar symptoms depression might represent one of two separate dimensions. The “mania” items of the extended CES-D were developed to cover the criteria of DSM-IV for manic and hypomanic episodes. The factor analyses revealed a single mania dimension. This dimension resembles a typical euphoria-activation cluster41 tapping items such as elation-happiness, decreased need for sleep, or extreme activity. While the results obtained by Bauer et al.17 for the ISS suggested that at least two separate factors—activation and well-being—underly the (hypo-) manic symptoms, these two factors did not show up in our data and actually constitute one factor. Further research need to clarify if it is better to distinguish between the dimensions “positive mood” and “activation” or if they are better be understood as a single, highly correlated dimension. However, two of the mania items were not associated with the mania dimension: “distractibility” and “irritability.” Pertaining to “distractibility,” we suppose that we as clinicians differentiate between the symptoms of poor concentration (as a depressive symptom) and distractibility (as part of the manic syndrome) more easily than lay people do. Indirect support for this concept comes from the correlation of both items being r = .48 (P < .001, n = 1,612). Of more theoretical importance, however, the item “irritability” would be considered a depression item according to our analysis. Although surprising at first, this has been shown by others too. For example, using a sample of 237 bipolar inpatients and relying on an interview measure that incorporated mania and depression items Cassidy et al.42 found that irritability and euphoria loaded on different factors. We found exactly the same in an independent sample of adolescents drawn from the general population.33 Originally we assumed that this result was specific for younger people, because according to DSM-IV the prominent mood of major depression episodes in children might not be depression or sadness but irritability. Several limitations have to be taken into account in interpreting the results. First, the sample was drawn from the general population of young adults. We do not know how many people have had a lifetime history of affective disorders or were currently suffering from affective symptoms. Therefore our results do not allow conclusions about the factorial structure of affective symptoms in general. Future research needs to investigate whether the factorial structure is comparable to the one obtained in samples with bipolar disorders. A related issue concerns that we do not know yet if we have to make a distinction between symptoms of mania endorsed in the general population and bipolar disorder.43 Another limitation is that we only included a self-report measure to assess current depressive and (hypo-) manic symptoms. There is, however, evidence that such instruments can be used reliably.44 Nevertheless, except for a more trait-like approach as in the area of high-risk research,22, 24, 25 the number of studies using self-report instruments to assess current bipolar symptoms is limited. Most factor analyses of manic symptoms typically used interview schedules or ward observations where depressive symptoms are not well represented.42, 45 Therefore it is hard to compare the present results with other studies. Furthermore, the currently available self-report scales use widely differing time frames and response formats.17, 19, 44 For example, if one scale is aimed to assess the current state within the last 24 hours (e.g., the ISS), another self-report measure asks for symptoms present in the previous week (e.g., the BDI), and a third covers a month (e.g., the SRMI). The correlation between these scales and their associations to other variables might be different. Finally, we do not know if this extended CES-D is a useful screening instrument for bipolar affective symptoms in the general population, since there are no data available yet that allow estimation of the sensitivity and specificity of this instrument for bipolar disorders. Recently a screening instrument for bipolar disorders showed good sensitivity and specificity,46 but this newly developed Mood Disorder Questionnaire only assesses manic symptoms to screen for lifetime bipolar disorders and not for current symptoms. In conclusion, we suggest that the present results show that the symptoms of bipolar disorder in a general population sample should not be understood as opposites of one continuum but seem to be described best as two independent factors. This would explain why two obviously so different states as depression and mania can occur simultaneously or so rapidly alternating that the episode has to be characterized with labels as “mixed mania” or “dysphoric mania.”10, 11, 12 To further evaluate the factorial structure of bipolar symptomatology and its correlates, future studies should use self-ratings and observer ratings of both mania and depression. Additionally, the current results should be replicated in a sample of bipolar patients in different states.
Acknowledgements  This work was made possible by the kind support of the Department of Culture and Education of the Baden-Wuerttemberg state and the cooperation of the schools within the area. We would like to express our gratitude to Sheri L. Johnson, Ph.D. (University of Miami) for helpful comments on a previous version of the manuscript. References  1.
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Department of Clinical and Physiological Psychology, University of Tuebingen, Tuebingen, Germany ☆ Supported by the Department of Culture and Education of the Baden-Wuerttemberg state. ☆☆ Address reprint requests to Thomas D. Meyer, Ph.D., Eberhard Karls Universitaet, Psychologisches Institut, Abteilung fuer Klinische und Physiologische Psychologie, Christophstrasse 2, 72072 Tuebingen, Germany. ★ 0010-440X/03/4402-0011$30.00/0 PII: S0010-440X(03)00045-2 doi:10.1053/comp.2003.50025 © 2003 Published by Elsevier Inc. | |
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